Amiodarone is extensively metaboliz

Amiodarone is extensively metabolized in the liver via CYP2C8 (under 1% unchanged in urine), and can effect the metabolism of numerous other drugs. The major metabolite of amiodarone is desethylamiodarone (DEA), which also has antiarrhythmic properties. The metabolism of amiodarone is inhibited by grapefruit juice, leading to elevated serum levels of amiodarone.

Результаты (латышский) 1:

Amiodarons tiek plaši metabolizēts aknās ar CYP2C8 (mazāk par 1% neizmainītā veidā ar urīnu), un var ietekmēt vielmaiņu daudziem citiem medikamentiem. Galvenais metabolīts amiodarona ir desethylamiodarone (DEA), kas ir arī antiaritmiskas īpašības. No amiodarona metabolismu inhibē greipfrūtu sulu, izraisot paaugstinātu seruma līmeni amiodaronu.